To ensure we are providing accurate and timely information, we only list articles on studies that are published in peer-reviewed periodicals and provide information to help you live well with PD. ​ CLICK FOR A FULL LIST OF ARTICLES AND RESEARCH STUDIES

​New research combines genetics, brain imaging, and clinical data to better understand Parkinson’s disease progression and identify potential treatment targets.
Adewale, Quadri, Ahmed Faraz Khan, Sue-Jin Lin, et al. “Patient-Centered Brain Transcriptomic and Multimodal Imaging Determinants of Clinical Progression, Physical Activity, and Treatment Needs in Parkinson’s Disease.” npj Parkinson’s Disease, Feb. 15, 2025. Available at: https://www.nature.com/articles/s41531-025-00878-4. (Nature)

Parkinson’s disease affects every person differently. Some individuals experience primarily movement-related symptoms, while others struggle with changes in cognition, mood, sleep, or daily functioning. One of the biggest challenges researchers face is understanding why Parkinson’s progresses differently from person to person and how treatments can be better tailored to individual needs.

A groundbreaking 2025 study published in npj Parkinson’s Disease used advanced computer modeling, brain imaging, and genetic data to explore the biological factors that drive Parkinson’s disease progression. Researchers analyzed information from people living with Parkinson’s disease, including brain scans, gene activity, clinical symptoms, and physical activity levels.

The study identified several biological pathways that appear to influence how Parkinson’s disease progresses over time. Researchers found that different combinations of genes and brain changes were linked to distinct symptom patterns, including motor symptoms, cognitive changes, mood disorders, and other non-motor symptoms.

One particularly exciting finding was the identification of potential drug targets that may someday help slow disease progression. Using computer simulations, researchers were able to predict which existing medications and biological pathways might have the greatest potential to modify the course of Parkinson’s disease.

The study also found that physical activity was associated with important biological processes related to inflammation and brain health, reinforcing previous research that exercise plays a critical role in living well with Parkinson’s disease.
While more research is needed before these findings lead to new treatments, the study represents an important step toward precision medicine—an approach that uses a person’s unique biology to guide treatment decisions.

As scientists continue to uncover the complex factors that influence Parkinson’s disease progression, personalized care and targeted therapies may become increasingly possible.

Stay Connected with PASWFL
The Parkinson’s Association of Southwest Florida provides free programs, education, support groups, exercise classes and resources for individuals living with Parkinson’s disease and their care partners throughout Southwest Florida.
​
Become a member today at https://parkinsonassociationswfl.org/signup.html and learn how our local programs can help you live well with Parkinson’s disease.

CLICK TO READ THE FULL STUDY
​The PASWFL offers a Rhythm and Motion Class for members and their care partners click here to learn more

PUBLISHED RESEARCH

 To ensure we are providing accurate and timely information, we only list articles on studies that are published in peer-reviewed periodicals and provide information to help you live well with PD.  To find additional papers and research CLICK HERE