What Can Parkinson Disease Be Mistaken For?

Parkinson’s disease (PD) is a complex neurological condition that often presents with a range of symptoms, including tremors, stiffness, slow movement, and balance problems. But what can Parkinson disease be mistaken for?
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​Due to the overlapping symptoms with other disorders, it’s not uncommon for PD to be misdiagnosed, especially in the early stages. Understanding these potential misdiagnoses is important for ensuring accurate treatment and support.

What Can Parkinson Disease Be Mistaken For?
Several other conditions can mimic Parkinson’s disease, making diagnosis a challenge even for experienced neurologists. Here are a few that are most commonly confused with PD:
1. Essential Tremor (ET)
Essential Tremor is one of the most frequently misdiagnosed conditions. While PD tremors often occur at rest, ET usually causes tremors during movement or when holding a posture. ET typically does not involve the slowness of movement (bradykinesia) or stiffness seen in PD.
2. Multiple System Atrophy (MSA)
MSA is a rare, progressive neurodegenerative disorder that shares many features with Parkinson’s disease, such as muscle rigidity and slowness. However, it progresses more rapidly and often involves significant issues with blood pressure regulation and bladder control.
3. Progressive Supranuclear Palsy (PSP)
PSP also mimics PD but tends to involve more balance problems and difficulties with eye movement early in the disease. Individuals with PSP may fall frequently and exhibit stiffness, but they often respond poorly to standard Parkinson’s medications.
4. Normal Pressure Hydrocephalus (NPH)
This condition involves an abnormal buildup of cerebrospinal fluid in the brain and can present with walking difficulties, memory issues, and urinary incontinence—symptoms that can sometimes resemble Parkinson’s disease.
5. Corticobasal Degeneration (CBD)
CBD affects one side of the body more severely and often includes symptoms like muscle stiffness, awkward limb posturing, and cognitive decline. Like PSP, it usually does not respond well to PD treatments.
6. Drug-Induced Parkinsonism
Certain medications, particularly antipsychotics and some anti-nausea drugs, can cause Parkinson-like symptoms. Unlike PD, these symptoms may improve or resolve after discontinuing the medication.

Correct diagnosis is essential because treatments vary depending on the underlying condition. A thorough evaluation by a movement disorder specialist—including neurological exams, imaging tests, and medical history—is often necessary for accurate diagnosis and effective care.

Supporting the Parkinson’s Community in Southwest Florida
Whether someone is newly diagnosed or has been living with PD for years, having access to knowledgeable support and reliable resources is key. For over twenty-five years, the Parkinson’s Association of Southwest Florida (PASWFL) has offered compassionate, effective programs that educate, enrich, and empower individuals and families living with Parkinson’s and related neurological diseases.

PASWFL provides over 25 free weekly programs and support groups tailored for those with PD and their care partners. There are no fees to join, and membership is open to all.

• Click here to sign up for the PASWFL newsletter
• Click here to become a PASWFL member for free

To explore more, visit www.parkinsonassociationswfl.org.