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Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool. Schaffrath, A., Schleyken, S., Seger, A. et al. Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool. npj Parkinsons Dis. 9, 14 (2023). https://doi.org/10.1038/s41531-023-00458-4

Misfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. Thus, α-synuclein aggregates are regarded as a biomarker for the development of a diagnosis. A new study investigated how alpha-synuclein levels detected in stool samples could predict Parkinson’s. The study found that:

• The new test was successful at detecting alpha-synuclein aggregates in stool samples.
• Stool from individuals with isolated rapid eye movement sleep behavior disorder (iRBD) showed significantly higher levels of alpha-synuclein aggregates than healthy .

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PUBLISHED RESEARCH

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