Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool. Schaffrath, A., Schleyken, S., Seger, A. et al. Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool. npj Parkinsons Dis. 9, 14 (2023). https://doi.org/10.1038/s41531-023-00458-4
Misfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. Thus, α-synuclein aggregates are regarded as a biomarker for the development of a diagnosis. A new study investigated how alpha-synuclein levels detected in stool samples could predict Parkinson’s. The study found that:
The new test was successful at detecting alpha-synuclein aggregates in stool samples.
Stool from individuals with isolated rapid eye movement sleep behavior disorder (iRBD) showed significantly higher levels of alpha-synuclein aggregates than healthy .
To ensure we are providing accurate and timely information, we only list articles on studies that are published in peer-reviewed periodicals and provide information to help you live well with PD. To find additional papers and researchCLICK HERE
Parkinson's Association of Southwest Florida 2575 Northbrooke Plaza Drive Suite#301, Naples, FL 34119 239-417-3465 Office@ParkinsonAssociationSWFL.org Hours of Operation: Monday - Thursday 9 am - 5 pm Friday 9 am - 3 pm
Has the Parkinson's Association of Southwest Florida impacted your life? Don't forget to leave us a review on Facebookor on Google.