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Coordinated Reset Vibrotactile Stimulation Induces Sustained Cumulative Benefits in Parkinson’s Disease
https: //www.frontier.org/articles/10.3389/fphys.2021.624317/full (4/6/2021)
1. Coordinated Reset Vibrotactile Stimulation Induces Sustained Cumulative Benefits in Parkinson’s Disease
Kristina J. Pfeifer1, Justus A. Kromer1, Alexander J. Cook1, Traci Hornbeck1,
Erika A. Lim1, Bruce J. P. Mortimer2, Adam S. Fogarty3, Summer S. Han1,4, Rohit Dhall5, Casey H. Halpern1 and Peter A. Tass1*
1 Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, United States, 2 Engineering Acoustics, Inc., Casselberry, FL, United States, 3 Department of Neurology, Stanford University School of Medicine, Stanford, CA, United States, 4 Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, CA, United States, 5 Center for Neurodegenerative Disorders, Department of Neurology, University of Arkansas 

Drug therapy and deep brain stimulation are effective therapies for many with Parkinson's Disease. However, because of the multiple concerns about deep brain stimulation this is not an adopted therapy by some patients. A recent small study by the neurology group from Stanford University demonstrated that wearing the vibrating glove shown above for two hours per day twice a day relieved many major symptoms of PD. The method of success relies on altering abnormal neural activity. This method of alteration is not new but the avenue of approach, the fingertips, with a large number of sensory neurons is. The pilot studies revealed the vibrations were well tolerated while producing improvements in PD symptoms. The glove remains in clinical trials. The group developing this modality of treatment is hoping in the near future to get FDA approval for treatment. 
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PUBLISHED RESEARCH

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