What Is PRKN2? Understanding a Rare Form of Parkinson’s Disease

When news broke that rock legend Ozzy Osbourne had been living with PRKN2, a rare form of Parkinson’s disease, many people were left wondering: What is PRKN2? How does it differ from typical Parkinson’s disease? And what does it mean for those diagnosed with it or supporting someone who is? PRKN2 may sound like a scientific mystery, but understanding it could make all the difference for families navigating the complexities of Parkinson’s. Whether you’ve recently received a diagnosis or are simply trying to learn more, this post will guide you through what PRKN2 is, who it affects, and where you can find trusted support right here in Southwest Florida.

What Is PRKN2?
PRKN2, often referred to as Parkin-type Parkinsonism, is a genetic form of Parkinson’s disease caused by mutations in the PRKN gene. This gene provides instructions for producing a protein called parkin, which plays a critical role in helping cells eliminate damaged mitochondria—the energy-producing parts of a cell. When the PRKN gene doesn’t function properly, nerve cells in the brain that control movement begin to deteriorate, leading to symptoms commonly associated with Parkinson’s disease.

PRKN2 is typically categorized as a type of early-onset Parkinson’s, meaning it often appears before the age of 50 and sometimes as early as the teenage years. It’s one of the most common genetic causes of Parkinsonism, but still relatively rare in the broader Parkinson’s population. People with PRKN2 may experience slower disease progression and a better response to medication, but they still face many of the same physical and emotional challenges as others living with Parkinson’s.

PRKN2 Early Onset Parkinson's

How Is PRKN2 Different?
Unlike more common idiopathic (non-genetic) Parkinson’s, PRKN2:

• Often begins earlier in life
• Progresses more slowly
• May include fewer cognitive symptoms
• Responds better to Levodopa, a common PD medication
• Typically runs in families, though it can appear sporadically

Genetic testing can help identify PRKN2, though many people are diagnosed based on symptoms and age of onset. Knowing you or a loved one has a genetic form of Parkinson’s can inform care strategies, treatment planning, and support options.

You can live well with PD

Why Support Matters
A diagnosis of any form of Parkinson’s can feel overwhelming. But with the right support and resources, individuals can maintain independence, quality of life, and emotional well-being.
For resources, referrals, and support in navigating Parkinson’s and related conditions, contact the Parkinson’s Association of Southwest Florida at www.parkinsonassociationswfl.org or call 239-417-3465.

For more than 25 years, PASWFL has provided free, high-quality services and programs to individuals and families affected by Parkinson’s disease in Southwest Florida. Their goal is simple: help people live well with PD, regardless of where they are in their journey.

Each week, PASWFL offers more than 25 free programs and support groups, including:

• Wellness and fitness classes
• Speech and cognitive therapy
• Educational seminars
• Support for care partners
• Support groups

There are no fees to become a member, and PASWFL welcomes anyone touched by PD.

Take the First Step Toward Living Well
If you suspect early Parkinson’s or have been recently diagnosed, you don’t have to face it alone.
👉 Click here to sign up for the PASWFL newsletter
👉 Click here to become a member (it's free!)
To learn more, visit www.paswfl.org and discover the power of support, education, and community.