How Does Parkinson's Disease Affect the Nervous System?

How Does Parkinson's Disease Affect the Nervous System?

Parkinson’s disease (PD) is a progressive neurological disorder that affects movement, coordination, and various functions of the nervous system. But how does Parkinson’s disease affect the nervous system, exactly?

Disruption of Dopamine-Producing Nerve Cells
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At the core of Parkinson’s lies a loss of dopamine—a crucial neurotransmitter responsible for transmitting messages between nerve cells that control movement. In PD, specific nerve cells in an area of the brain called the substantia nigra gradually degenerate. As these neurons die, dopamine levels drop, leading to hallmark symptoms such as:

• Tremors
• Muscle stiffness
• Slowed movements (bradykinesia)
• Postural instability
• Changes in balance and coordination

​Understanding the Impact of Parkinson’s on the Brain and Body
As Parkinson’s progresses, it can also affect other parts of the nervous system, leading to non-motor symptoms like:

• Sleep disturbances
• Mood changes (depression or anxiety)
• Autonomic dysfunction (such as blood pressure changes or constipation)
• Cognitive challenges

Support and Resources from PASWFL
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For over twenty-five years, the Parkinson’s Association of Southwest Florida (PASWFL) has been committed to improving the lives of those impacted by Parkinson’s and related neurological diseases. They provide evidence-based programs and services designed to support both individuals living with PD and their care partners.

Each week, PASWFL offers more than 25 FREE programs and support groups, including movement classes, educational workshops, and wellness activities—all aimed at enhancing quality of life.
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 There are no fees to become a PASWFL member, and registration is simple and confidential.
 Learn more about PASWFL at: www.parkinsonassociationswfl.org

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