What Is Atypical Parkinsonism? Understanding the Differences From Parkinson’s Disease

When people first notice symptoms like tremors, muscle stiffness, or trouble with balance, their first thought might be Parkinson’s disease. But not all Parkinson-like symptoms point to that diagnosis. Some people are living with what’s called Atypical Parkinsonism—a group of neurological conditions that resemble Parkinson’s but have important differences.

👉 So, what exactly is Atypical Parkinsonism, and how does it differ from Parkinson’s disease? Let’s take a closer look.

What Is Atypical Parkinsonism?
Atypical Parkinsonism refers to a group of disorders that share some symptoms with Parkinson’s disease but don’t follow the same pattern. These conditions usually progress more quickly, may affect different parts of the body, and often respond poorly—or not at all—to standard Parkinson’s medications like Levodopa.

Types of Atypical Parkinsonism
Some of the most recognized forms include:

1. Progressive Supranuclear Palsy (PSP)
   – Causes problems with walking, balance, eye movements, and thinking.
2. Multiple System Atrophy (MSA)
   – Affects movement, balance, and automatic body functions such as blood pressure and bladder control.
3. Corticobasal Degeneration (CBD)
   – Often starts on one side of the body, leading to stiffness, jerky movements, and difficulty with coordination.
4. Lewy Body Dementia (LBD)
   – Causes movement issues along with significant cognitive changes, including memory problems and hallucinations.

How Atypical Parkinsonism Differs From Parkinson’s Disease

• Medication Response: While people with Parkinson’s disease often respond well to dopamine-replacement medications, those with atypical forms typically don’t.
• Progression Speed: Atypical conditions tend to move faster than Parkinson’s disease.
• Symptoms Beyond Movement: Many forms of atypical Parkinsonism affect thinking, vision, speech, and automatic body functions, in addition to movement.

Why Early Recognition Matters
Getting the right diagnosis early can help families plan ahead, connect with specialists, and access supportive therapies. While treatment options are more limited than for Parkinson’s disease, lifestyle strategies, support services, and targeted therapies can still make a meaningful difference.

Why Support Matters
​A diagnosis of any form of Parkinson’s can feel overwhelming. But with the right support and resources, individuals can maintain independence, quality of life, and emotional well-being.
For resources, referrals, and support in navigating Parkinson’s and related conditions, contact the Parkinson’s Association of Southwest Florida at www.paswfl.org or call 239-417-3465.

For over 25 years, PASWFL has provided free, high-quality services and programs to individuals and families touched by Parkinson’s disease in Southwest Florida. Their goal is simple: help people live well with PD, regardless of where they are in their journey.
Each week, PASWFL offers more than 25 free programs and support groups, including:

• Wellness and fitness classes
• Speech Exercise classes
• Educational seminars
• Support for care partners
• Support groups

There are no fees to become a member, and PASWFL welcomes anyone touched by PD.
Take the First Step Toward Living Well
If you suspect early Parkinson’s or have been recently diagnosed, you don’t have to face it alone.
👉 Click here to sign up for the PASWFL newsletter
👉 Click here to become a member (it's free!)
To learn more, visit www.paswfl.org and discover the power of support, education, and community.