What Is the Best Medication for Parkinson's Disease?

When someone is diagnosed with Parkinson’s disease, one of the first questions that often arises is: “What is the best medication for Parkinson’s disease?” While there isn’t a one-size-fits-all answer, understanding the most effective medications and how they work can help individuals with Parkinson’s and their care partners make informed decisions.

What Is the Best Medication for Parkinson’s Disease?
The most well-known and commonly prescribed medication for Parkinson’s disease is Levodopa (also known as L-DOPA), often combined with Carbidopa. Levodopa is considered the gold standard for managing Parkinson’s symptoms because it directly addresses the dopamine deficiency in the brain—dopamine being the chemical that Parkinson’s disease gradually reduces.

Carbidopa is added to prevent Levodopa from breaking down in the bloodstream before reaching the brain. This combination helps reduce side effects like nausea and enhances the effectiveness of the medication.

Other important classes of medications include:

• Dopamine agonists (e.g., Pramipexole, Ropinirole): These mimic dopamine activity in the brain and are sometimes used in early stages or alongside Levodopa in more advanced stages.
• MAO-B inhibitors (e.g., Selegiline, Rasagiline): These block the breakdown of dopamine in the brain, helping to prolong its effects.
• COMT inhibitors (e.g., Entacapone): These are often added to Levodopa therapy to extend its duration and reduce “off” times.
• Anticholinergics and Amantadine: These may help with tremors or reduce medication-induced dyskinesias (involuntary movements).

​
While Levodopa remains the most effective medication overall, the best treatment plan depends on the individual's symptoms, age, lifestyle, and response to medication. Neurologists often adjust combinations and dosages over time to optimize results.

A Personalized Approach Is Key
Parkinson’s is a complex and evolving condition. What works well for one person may not be ideal for another. That’s why a neurologist or movement disorder specialist is essential for tailoring medication to a patient’s specific needs.
​
Regular follow-ups are crucial, as symptoms can change and side effects may emerge. Some people may also benefit from non-pharmacological treatments, such as physical therapy, occupational therapy, or even deep brain stimulation (DBS) in advanced cases.

Support from the Parkinson’s Association of Southwest Florida
Medication is only part of the journey. Emotional, social, and educational support plays a major role in improving quality of life. For more than twenty-five years, the Parkinson’s Association of Southwest Florida (PASWFL) has been a dedicated resource for those living with PD in the region.

Each week, PASWFL offers more than 25 free programs and support groups for people with Parkinson’s and their care partners. These include movement classes, speech therapy, caregiver support, and more. There are no fees to join, and the support is both life-changing and empowering.
​
To learn more and become part of this supportive community:

• Click here to sign up for their free newsletter
• Click here to become a free member

Visit www.parkinsonassociationswfl.org for details about services and upcoming events.